Abstract: This paper provided an overview of epigenetic regulation of Arabidopsis’s response to the environment change. Tthe role of histone vriant H2A.Z in a variety of responses in Arabidopsis was discussed. And the critical function of the histone methylation modification in the process of the regulation of Arabidopsis flowering was described. Last, some research results of epigenetics in the responses to environment in Arabidopsis were list in this paper.