Abstract: 【Objective/Meaning】The cross-provincial counterpart assistance was an important way for poverty alleviation in the current national targeted poverty alleviation strategy. The research on the long-term strategy of cross-provincial counterpart assistance of Guangzhou City to Bijie Region in the south of Guizhou Province was beneficial to the effective implementation of the national targeted poverty alleviation strategy. 【Methods/Procedures】By taking the model of targeted poverty alleviation of cross-provincial counterpart assistance of Guangzhou City to Bijie Region in the south of Guizhou province as an example, the qualitative and quantitative analysis on the internal and external environment in Guangzhou, the south of Guizhou Province and Bijie Region was carried out by using the theory of SWOT.【Results/Conclusions】The targeted poverty alleviation of cross-provincial counterpart assistance of Guangzhou City to Bijie Region in the south of Guizhou Province was the model of “advantage + opportunity” targeted poverty alleviation. The internal disadvantages of both Guangzhou and Bijie Region in the south of Guizhou Province far outweighed their external threats. Based on this, the development ideas were put forward including setting the long-term goals of counterpart assistance, effectively planning and designing the phased goals, and setting the development strategies of counterpart assistance.